Vaccine is not as infectious as one may hope, with ’90s controls and camera angles being at the forefront; it could easily dissuade newcomers. Handheld mode offers a more intimate take, meaning music is at the core for holding the tension – in this one area it does a stellar job. Increasing the picture size to a TV regrettably shows the ugly nature of the graphics however, not only hindering gameplay but the overall experience. Story is something that can either be taken or left, though don’t expect much in terms of a pay-off considering the challenge in reaching the true finale. Finally, the randomised environments at the heart of Vaccine are a clever idea but, like in the Wii U original, serve up a flawed overall experience.